Crumbs, Galla and Xpd are required for kinesin-5 regulation in mitosis and organ growth in Drosophila
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چکیده
منابع مشابه
Crumbs and Xpd in mitosis
Mitosis is a fundamental process for chromosome segregation in all multicellular organisms. Misregulation of mitosis can cause genetic instability and cancer. Thus, identification of the genes involved in the regulation of mitosis is important for understanding the mechanism of chromosome segregation and genome instability. Unbiased genetic screens are powerful tools for identifying new gene fu...
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Multiple Protein Phosphatases Are Required for Mitosis in Drosophila
BACKGROUND Approximately one-third of the Drosophila kinome has been ascribed some cell-cycle function. However, little is known about which of its 117 protein phosphatases (PPs) or subunits have counteracting roles. RESULTS We investigated mitotic roles of PPs through systematic RNAi. We found that G(2)-M progression requires Puckered, the JNK MAP-kinase inhibitory phosphatase and PP2C in ad...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2020
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.246801